Safe, effective and inexpensive indigenous remedies are gaining popularity among the people of both urban and rural areas of India. The present paper provides first-hand information on ethnomedicinal plants recorded from agro-forestry systems and home gardens from Mizoram (an Indo-Burma hotspot region). Medicinal uses of plants were assessed on the basis of exhaustive interviews with local physicians practising indigenous system of medicine, home garden owners and various tribal groups relying on agroforestry systems of Mizoram, North East (NE) India. The survey results into the uses of 54 ethnomedicinal plant species belonging to 52 genera and 35 families of flowering plants. Key words: Ethnomedicines, home garden, landscape, conservation, threatened