Antinociceptive and anti-inflammatory activities of Trigonella foenum-greacum seeds

AMINE LAROUBI, LOUBNA FAROUK, RACHIDA ABOUFATIMA, ABDELFETTAH BENSALAH, ABDELMAJID ZYAD, AHMED BENHAREF, ABDELAH BAGRI, ABDERAHMAN CHAIT

Abstract

Trigonella foenum-graecum L. (Leguminosae), known in Morocco as “Helba”, is used in folk medicine for its anti-ulcer, anti-inflammatory, cicatrizing activities and to treat various pain-related physiological states. In present study, we attempted to verify the possible antinociceptive and anti-inflammatory activities of different extracts obtained from the seeds of this plant. Three experimental models were used (i.e. acetic acid, formalin, and hot-plate tests) in order to characterize both the analgesic and the anti inflammatory effects. Dichloromethane (350 and 500 mg/kg), ethyl acetate [(EAE) (350 and 500 mg/kg)],aqueous (500 mg/kg) and butanolic (500 mg/kg) extracts significantly and in a dose-dependent manner reduced the pain induced by IP injection of acetic acid. In the formalin test, the extracts, except EAE, significantly reduced the painful stimulus but only in the early phase of the test. On the contrary, these extracts, except EAE, were ineffective in increasing the latency of licking or jumping in the hot-plate test. These results suggest that the compounds present in the extracts activated both central and peripheral mechanisms to elicit the analgesic and anti-inflammatory effects. However, pharmacological and chemical studies are continued in order to characterize these mechanisms and also to identify the active principles present in each extract.
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